Accelerated atherosclerosis in HGPS

Diabetes-accelerated atherosclerosis and inflammation.

Diabetes-Accelerated Atherosclerosis and Inflammation To the Editor: We read with interest the Letter to the Editor by Marfella et al1 in response to our review article on the role of glucose and lipids in diabetes-accelerated atherosclerosis.2 Marfella et al1 point out that inflammation is likely to play important roles in diabetes-associated cardiovascular events. Indeed, in our review articl...

Accelerated Atherosclerosis and Calcification in Vein Grafts

Vein grafts fail due to development of intimal hyperplasia and accelerated atherosclerosis. Many murine genetic models in which genes are overexpressed, deleted, or mutated have been introduced recently. Therefore, mouse models are very well suited to dissect the relative contribution of different genes in the development of accelerated atherosclerosis. In the present study, we evaluated whethe...

Diabetes-induced accelerated atherosclerosis in swine.

Patients with diabetes are at higher risk for atherosclerotic disease than nondiabetic individuals with other comparable risk factors. Studies examining mechanisms underlying diabetes-accelerated atherosclerosis have been limited by the lack of suitable humanoid animal models. In this study, diabetes was superimposed on a well-characterized swine model of atherosclerosis by injection of the bet...

Accelerated atherosclerosis in autoimmune rheumatic diseases.

Atherosclerosis is a multifactorial process that commences in childhood but manifests clinically later in life. Atherosclerosis is increasingly considered an immune system–mediated process of the vascular system. The presence of macrophages and activated lymphocytes within atherosclerotic plaques supports the concept of atherosclerosis as an immune system–mediated inflammatory disorder.1,2 Infl...

C . A . Genco - accelerated Atherosclerosis Porphyromonas gingivalis